Publications

Nanopore Sequencing Enables Broad Detection and Surveillance of Tick-Borne Pathogens in Ixodes scapularisUNDER REVIEW

Brandon Assi, Noelle Khalil, Jesse Matijevic, Evan Rogers, Christian H. Eggers, Goudarz Molaei, Paul Wolujewicz

iScience (submitted)

METAGENOMICSNANOPOREPUBLIC HEALTH
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Tick surveillance

Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids

Stankovic I, Smit P, Cross J, Rai A, Wolujewicz P, Greening D, Colak D

Translational Psychiatry (2025) 15(1):393

ASDORGANOIDSEXTRACELLULAR VESICLES
DOI PDF
EV profiling

Integrative computational analyses implicate regulatory genomic elements contributing to spina bifida

Wolujewicz P, Aguiar-Pulido V, Thareja G, Suhre K, Elemento O, Finnell RH, Ross ME

Genetics in Medicine Open (2024) 2:101894

DEEP LEARNINGSPINA BIFIDA
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Regulatory elements

Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids

Stankovic I, Notaras M, Wolujewicz P, Lu T, Lis R, Ross ME, Colak D

Translational Psychiatry (2024) 14(1):53

SCHIZOPHRENIABLOOD-BRAIN BARRIERORGANOIDS
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BBB permeability

A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele

Crane-Smith Z, De Castro SCP, Nikolopoulou E, Wolujewicz P, Smedley D, Lei Y, Mather E, Santos C, Hopkinson M, Pitsillides AA, Genomics England Research Consortium, Finnell RH, Ross ME, Copp AJ, Greene NDE

Human Molecular Genetics (2023) 32(17):2681–2692

GRHL2MOUSE MODELNON-CODING
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Grhl2 mutation

Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

Allen M, Huang BS, Notaras MJ, Lodhi A, Barrio-Alonso E, Lituma PJ, Wolujewicz P, Witztum J, Longo F, Chen M, Greening DW, Klann E, Ross ME, Liston C, Colak D

Molecular Psychiatry (2022) 27(5):2470–2484

AUTISMASTROCYTESCALCIUM SIGNALING
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Astrocyte signaling

Systems biology analysis of human genomes points to key pathways conferring spina bifida risk

Aguiar-Pulido V, Wolujewicz P, Martinez-Fundichely A, Elhaik E, Thareja G, Abdel Aleem A, Chalhoub N, Cuykendall T, Al-Zamer J, Lei Y, El-Bashir H, Musser JM, Al-Kaabi A, Shaw GM, Khurana E, Suhre K, Mason CE, Elemento O, Finnell RH, Ross ME

Proceedings of the National Academy of Sciences (2021) 118(51):e2106844118

SYSTEMS BIOLOGYSPINA BIFIDAPNAS
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Systems biology

Unraveling the complex genetics of neural tube defects: From biological models to human genomics and back

Wolujewicz P, Steele JW, Kaltschmidt JA, Finnell RH, Ross ME

Genesis (2021) 59(11):e23459

REVIEWNEURAL TUBE DEFECTS
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NTD genetics

Genome-wide investigation identifies a rare copy-number variant burden associated with human spina bifida

Wolujewicz P, Aguiar-Pulido V, AbdelAleem A, Nair V, Thareja G, Suhre K, Shaw GM, Finnell RH, Elemento O, Ross ME

Genetics in Medicine (2021) 23(7):1211–1218

COPY NUMBER VARIANTSSPINA BIFIDA
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CNV analysis

A crowdsourced set of curated structural variants for the human genome

Chapman LM, Spies N, Pai P, Lim CS, Carroll A, Narzisi G, Watson CM, Proukakis C, Clarke WE, Nariai N, Dawson E, Jones G, Blankenberg D, Brueffer C, Xiao C, Kolora SRR, Alexander N, Wolujewicz P, Ahmed AE, Smith G, et al.

PLoS Computational Biology (2020) 16(6):e1007933

STRUCTURAL VARIANTSCROWDSOURCEDBENCHMARKING
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Structural variants

The search for genetic determinants of human neural tube defects

Wolujewicz P, Ross ME

Current Opinion in Pediatrics (2019) 31(6):739–746

REVIEWNEURAL TUBE DEFECTS
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NTD determinants

Astrocyte-produced leukemia inhibitory factor expands the neural stem/progenitor pool following perinatal hypoxia-ischemia

Felling RJ, Covey MV, Wolujewicz P, Batish M, Levison SW

Journal of Neuroscience Research (2016) 94(12):1531–1545

ASTROCYTESNEURAL PROGENITORSHYPOXIA-ISCHEMIA
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LIF signaling

Profiling stem cell states in three-dimensional biomaterial niches using high content image informatics

Dhaliwal A, Brenner M, Wolujewicz P, Zhang Z, Mao Y, Batish M, Kohn J, Moghe PV

Acta Biomaterialia (2016) 45:98–109

STEM CELLSBIOMATERIALSIMAGE ANALYSIS
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Stem cell profiling